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[CAS NO. 67747-09-5]??Prochloraz

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PRODUCTS SPECIFICATIONS [67747-09-5]

Catalog
HY-B0845
Brand
MCE
CAS
67747-09-5

DESCRIPTION [67747-09-5]

Overview

MDL-
Molecular Weight376.67
Molecular FormulaC15H16Cl3N3O2
SMILESO=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl

For research use only. We do not sell to patients.

Summary

Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC 50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC 50 of 1 μM [1] [2] .


IC50 & Target

IC50: 25 μM (Estrogen receptor), 4 μM (Androgen receptor) and 0.3 μM (Aromatase) [2]
EC50: 1 μM (Aryl hydrocarbon receptor (AhR)) [2]


In Vitro

Prochloraz has a strong inhibition of the microsomal cytochrome P-450 dependent 14α-demethylation of lanosterol during ergosterol biosynthesis, which leads to membrane disruption and eventually to cell death [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

In vivo Prochloraz acts as an antiandrogen in the Hershberger assay by reducing weights of reproductive organs, affecting androgen-regulated gene expressions in the prostate and increasing luteinizing hormone levels. In order to investigate the developmental effects of Prochloraz, pregnant Wistar dams were dosed perinatally with 30 mg/kg Prochloraz. Results show that Prochloraz significantly reduces plasma and testicular testosterone levels in gestational day 21 male foetuses, whereas testicular progesterone was increased. Gestational length is increased by Prochloraz [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 663.71 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6548 mL 13.2742 mL 26.5484 mL
5 mM 0.5310 mL 2.6548 mL 5.3097 mL
10 mM 0.2655 mL 1.3274 mL 2.6548 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 1.98 mg/mL (5.26 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

1H-Imidazole-1-carboxamide, N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-
N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide
BTS 40542
Prochloraz
BTS 40542-7877
Sportak
KI 835
Prelude
DMI
Sportake
Mirage
Mirage (pesticide)
Plocloraz
N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide

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