[CAS NO. 67979-25-3]??Aurantio-obtusin
PRODUCTS SPECIFICATIONS [67979-25-3]
DESCRIPTION [67979-25-3]
Overview
| MDL | MFCD13194886 |
|---|---|
| Molecular Weight | 330.29 |
| Molecular Formula | C17H14O7 |
| SMILES | O=C1C2=C(C=C(C)C(O)=C2OC)C(C3=CC(O)=C(OC)C(O)=C13)=O |
Summary
Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae , with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities [1] [2] [3] . Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator [2] . Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases [3] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL ( 75.69 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0276 mL | 15.1382 mL | 30.2764 mL |
| 5 mM | 0.6055 mL | 3.0276 mL | 6.0553 mL |
| 10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL |
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1.
References
- [1] Hou J, et al. Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway. Molecules. 2018 Nov 27;23(12).
- [2] Li S, et al. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 2015 Jul;128(3):108-15.
- [3] Kim M, et al. Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models. J Agric Food Chem. 2015 Oct 21;63(41):9037-46.
Synonyms