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[CAS NO. 70288-86-7]??Ivermectin (MK-933)

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PRODUCTS SPECIFICATIONS [70288-86-7]

Catalog
SLK-S1351
Brand
Selleck
CAS
70288-86-7

DESCRIPTION [70288-86-7]

Overview

MDL-
Molecular Weight875.09
Molecular FormulaC48H74O14
SMILES-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.1427 mL5.7137 mL11.4274 mL
5 mM0.2285 mL1.1427 mL2.2855 mL
10 mM0.1143 mL0.5714 mL1.1427 mL
50 mM0.0229 mL0.1143 mL0.2285 mL

Description

Ivermectin (MK-933, IVM) is a glutamate-gated (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of and . Ivermectin has potent antiviral activity towards both and . Ivermectin induces through the AKT/mTOR signaling pathway and .

Targets

chloride channel [3]

In vitro

Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons. Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae.


Synonyms

Ivermectin
Hyvermectin
MK 933
22,23-Dihydroavermectin B1
Ivomec
Eqvalan
Heartgard 30
Mectizan
Pandex
Phoenectin
Jetamec
Equimec
Equimec Paste
L 640471
Cardomec
Zimecterin
Cardotek 30
Stromectol
Ivectin
Heartgard
Vermic
Uvemec
Cevamec
Oramec
Ivertin
Noramectin
Ivosint
Bimectin
Vetmec
Noromectin
Bovinet
Bagomectina
Equirat Gold
Cardotek Plus
Equimectrin
Virbamec LA
Iversalt
Oramectin
Ivermec
Ivomec Gold
Mukhnet I
Solantra
Soolantra
Ivermectin B1a-ivermectin B1b mixture

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