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[CAS NO. 7177-50-6]??Nafcillin Sodium

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PRODUCTS SPECIFICATIONS [7177-50-6]

Catalog
SLK-S4042
Brand
Selleck
CAS
7177-50-6

DESCRIPTION [7177-50-6]

Overview

MDL-
Molecular Weight454.47
Molecular FormulaC21H21N2O5S.H2O.Na
SMILESC(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C4=C(C=CC3OCC)C=CC=C4)C2=O)(SC1(C)C)[H].[Na].O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.2004 mL11.0018 mL22.0037 mL
5 mM0.4401 mL2.2004 mL4.4007 mL
10 mM0.2200 mL1.1002 mL2.2004 mL
50 mM0.0440 mL0.2200 mL0.4401 mL

Description

Nafcillin sodium (CL 8491) reversibly inhibits with of 33 mM.

Targets

β-lactamase [1]
33 mM(Kd)

In vitro

Nafcillin sodium inactivates β-lactamase through forming a covalent acyl-enzyme intermediate with β-lactamase via Ser-70. At concentrations above 80 mM, Nafcillin displays complete inhibition of β-lactamase within 200 s. Upon removal of the excess Nafcillin, the inhibited enzyme can be re-activated completely, with a rate constant of 2×10/s (25 ℃). Nafcillin sodium is activity against penicillin-resistant staphylococci. The minimal concentration necessary for antistaphylococcic activity in vitro ranges from 0.2 μg/mL to 2 μg/mL.


Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
Sodium nafcillin monohydrate
Sodium 6-(2-ethoxy-1-naphthamido)penicillanate monohydrate
Nafcillin sodium hydrate

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