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[CAS NO. 74285-86-2]??Triptophenolide

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PRODUCTS SPECIFICATIONS [74285-86-2]

Catalog
HY-N0475
Brand
MCE
CAS
74285-86-2

DESCRIPTION [74285-86-2]

Overview

MDL-
Molecular Weight312.40
Molecular FormulaC20H24O3
SMILESO=C1C(CC[C@]2(C)C3=C(CC[C@]24[H])C(O)=C(C(C)C)C=C3)=C4CO1

For research use only. We do not sell to patients.

Summary

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii . IC50 value: Target: In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1]. In vivo:


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 320.10 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2010 mL 16.0051 mL 32.0102 mL
5 mM 0.6402 mL 3.2010 mL 6.4020 mL
10 mM 0.3201 mL 1.6005 mL 3.2010 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

* All of the co-solvents are available by MCE.


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