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[CAS NO. 76144-81-5]??Meldonium

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PRODUCTS SPECIFICATIONS [76144-81-5]

Catalog
HY-B1836
Brand
MCE
CAS
76144-81-5

DESCRIPTION [76144-81-5]

Overview

MDL-
Molecular Weight146.19
Molecular FormulaC6H14N2O2
SMILESC[N+](C)(C)NCCC([O-])=O

For research use only. We do not sell to patients.


Summary

Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2 . Mildronate (Meldonium) exhibits IC 50 values of 34-62 μM for human recombinant BBOX and an EC 50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes [1] .


IC50 & Target

IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT01800357 Xijing Hospital
Acute Ischemic Stroke
January 2013 Phase 2
NCT01831011 Xijing Hospital
Acute Ischemic Stroke
July 2008 Phase 2

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

H 2 O : 50 mg/mL ( 342.02 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8404 mL 34.2021 mL 68.4041 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL
10 mM 0.6840 mL 3.4202 mL 6.8404 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (684.04 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.


Synonyms

Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt
3-(2,2,2-Trimethylhydrazinium)propionate
Quaterin
Mildronate
1,1,1-Trimethyl-2-(2-carboxyethyl)hydrazine zwitterion
MET 88
Meldonium
Vasonat
Hydrinol
Idrinol
3-[(Trimethylazaniumyl)amino]propanoate

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