[CAS NO. 81-14-1]??Musk ketone

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PRODUCTS SPECIFICATIONS [81-14-1]

Catalog

HY-N2045

Brand

MCE

CAS

81-14-1

DESCRIPTION [81-14-1]

Overview

MDL	-
Molecular Weight	294.30
Molecular Formula	C14H18N2O5
SMILES	CC(C1=C(C)C([N+]([O-])=O)=C(C(C)(C)C)C([N+]([O-])=O)=C1C)=O

For research use only. We do not sell to patients.

Summary

Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis ^[1] ^[2] ^[3] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL ( 424.74 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3979 mL	16.9895 mL	33.9789 mL
5 mM	0.6796 mL	3.3979 mL	6.7958 mL
10 mM	0.3398 mL	1.6989 mL	3.3979 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62.
[2] Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96.
[3] Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9.

Synonyms

Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-

Acetophenone, 4′-tert-butyl-2′,6′-dimethyl-3′,5′-dinitro-

1-[4-(1,1-Dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]ethanone

4-Aceto-3,5-dimethyl-2,6-dinitro-tert-butylbenzene

4′-tert-Butyl-2′,6′-dimethyl-3′,5′-dinitroacetophenone

Musk ketone

3,5-Dinitro-4-tert-butyl-2,6-dimethylacetophenone

3,5-Dinitro-2,6-dimethyl-4-tert-butylacetophenone

2,6 Dimethyl-4-tert-butyl-3,5-dinitroacetophenone

4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone

2,6-Dimethyl-3,5-dinitro-4-tert-butyl acetophenone

NSC 15339

1-tert-Butyl-3,5-dimethyl-2,6-dinitro-4-acetylbenzene

1-(4-(tert-Butyl)-2,6-dimethyl-3,5-dinitrophenyl)ethan-1-one

1-(4-tert-Butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanone

1-(4-tert-Butyl-2,6-dimethyl-3,5-dinitrophenyl)ethan-1-one

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