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[CAS NO. 84-36-6]??Syrosingopine (Su-3118)

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PRODUCTS SPECIFICATIONS [84-36-6]

Catalog
SLK-S9907
Brand
Selleck
CAS
84-36-6

DESCRIPTION [84-36-6]

Overview

MDLMFCD00017411
Molecular Weight666.71
Molecular FormulaC35H42N2O11
SMILESC(OC)(=O)[C@H]1[C@]2(C[C@@]3(C4=C(C=5C(N4)=CC(OC)=CC5)CCN3C[C@]2(C[C@@H](OC(=O)C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)[C@@H]1OC)[H])[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.4999 mL7.4995 mL14.9990 mL
5 mM0.3000 mL1.4999 mL2.9998 mL
10 mM0.1500 mL0.7500 mL1.4999 mL
50 mM0.0300 mL0.1500 mL0.3000 mL

Description

Syrosingopine (Su-3118) is a dual and inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.

Targets

MCT4 [1]
(in HAP1 cell)
MCT1 [1]
(in HAP1 cell)
40 nM2500 nM

In vitro

Syrosingopine treatment leads to high intracellular lactate levels and thereby end-product inhibition of lactate dehydrogenase by inhibiting the Lactate Transporters MCT1 and MCT4. The loss of NAD+ regeneration capacity due to combined metformin and syrosingopine treatment results in glycolytic blockade, leading to ATP depletion and cell death. [1]


Synonyms

Yohimban-16-carboxylic acid, 18-[[4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-, methyl ester, (3β,16β,17α,18β,20α)-
3β,20α-Yohimban-16β-carboxylic acid, 18β-hydroxy-11,17α-dimethoxy-, methyl ester, 4-hydroxy-3,5-dimethoxybenzoate (ester) ethyl carbonate (ester)
Reserpic acid, methyl ester, ester with syringic acid, ethyl carbonate
Carbethoxysyringoyl methylreserpate
Methyl carbethoxysyringoyl reserpate
Methyl reserpate ester of syringic acid ethyl carbonate
Singoserp
Syringic acid ethyl carbonate ester with methyl reserpate
Syrosingopine
Su 3118
Isotense
Syrosingopin
Syringopine
Siringina
Seniramin
Londomin
Raunova
NSC 77030
SML 1908

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