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[CAS NO. 85643-19-2]??Curculigoside

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PRODUCTS SPECIFICATIONS [85643-19-2]

Catalog
HY-N0705
Brand
MCE
CAS
85643-19-2

DESCRIPTION [85643-19-2]

Overview

MDLMFCD00800689
Molecular Weight466.44
Molecular FormulaC22H26O11
SMILESO=C(C(C(OC)=CC=C1)=C1OC)OCC(C=C(O)C=C2)=C2O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO

For research use only. We do not sell to patients.


Summary

Curculigoside is the main saponin in C. orchioide , exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway [1] .


IC50 & Target

JAK; STAT; NF-κB [1]


In Vitro

Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 μg/ml in MH7A cells [1] .
Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [1]

Cell Line: MH7A cells
Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml
Incubation Time: 72 hours
Result: Had inhibitory effect on MH7A cells.

Western Blot Analysis [1]

Cell Line: MH7A cells
Concentration: 4 μg/ml; 64 μg/ml
Incubation Time: 24 hours
Result: Downregulated JAK1, JAK3 and STAT3 protein expression.

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 214.39 mM ; Need ultrasonic)

H 2 O : ≥ 2 mg/mL ( 4.29 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1439 mL 10.7195 mL 21.4390 mL
5 mM 0.4288 mL 2.1439 mL 4.2878 mL
10 mM 0.2144 mL 1.0719 mL 2.1439 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

β-D-Glucopyranoside, 2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl
2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl β-D-glucopyranoside
Curculigoside
Curculigoside A
Curculigoside I
Curculigoside 1

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