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[CAS NO. 860-79-7]??Cyclovirobuxine D

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PRODUCTS SPECIFICATIONS [860-79-7]

Catalog
HY-N0107
Brand
MCE
CAS
860-79-7

DESCRIPTION [860-79-7]

Overview

MDL-
Molecular Weight402.66
Molecular FormulaC26H46N2O
SMILESC[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C

For research use only. We do not sell to patients.

Summary

Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla . Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR [1] . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis [2] . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction [3] .


In Vitro

Cyclovirobuxine D (0-240 μM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 μM [2] .
Cyclovirobuxine D (0-120 μM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner [2] .
Cyclovirobuxine D (0-120 μM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis. Cyclovirobuxine D (0-120 μM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, 120 and 240 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells

Cell Cycle Analysis [2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 μM
Incubation Time: 48 hours
Result: Arrested cell cycle progressions of MGC-803 and MKN28 cells.

Apoptosis Analysis [2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 μM
Incubation Time: 48 hours
Result: Induced apoptosis of MGC-803 and MKN28 cells.

Western Blot Analysis [2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 μM
Incubation Time: 48 hours
Result: Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

Ethanol : 13 mg/mL ( 32.29 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4835 mL 12.4174 mL 24.8348 mL
5 mM 0.4967 mL 2.4835 mL 4.9670 mL
10 mM 0.2483 mL 1.2417 mL 2.4835 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% EtOH >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 1.08 mg/mL (2.68 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.08 mg/mL (2.68 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% EtOH >> 90% corn oil

    Solubility: ≥ 1.08 mg/mL (2.68 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

9,19-Cyclopregnan-16-ol, 4,4,14-trimethyl-3,20-bis(methylamino)-, (3β,5α,16α,20S)-
9,19-Cyclo-5α,9β-pregnan-16α-ol, 4,4,14-trimethyl-3β,20α-bis(methylamino)-
1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene, 9,19-cyclopregnan-16-ol deriv.
(3β,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol
Cyclovirobuxine
Cyclovirobuxine D
Bebuxine
Cyclovirobuxin D
NSC 91722
Cyclovirobuxinum D
(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol
CVB-D

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