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[CAS NO. 86088-83-7]??Fibronectin

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PRODUCTS SPECIFICATIONS [86088-83-7]

Catalog
HY-P3160
Brand
MCE
CAS
86088-83-7

DESCRIPTION [86088-83-7]

Overview

MDL-
Molecular Weight-
Molecular FormulaUnspecified
SMILES-

For research use only. We do not sell to patients.

Summary

Fibronectin, a glycoprotein (~500 kDa) present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans [1] .


In Vitro

Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury. Increases in plasma Fibronectin (FN) has been reported after inflammation, trauma, and diseases such as atherosclerosis. Tobacco-related lung diseases are characterized by increased accumulation of Fibronectin (FN) which can be induced by nicotine. We found significant increases of plasma Fibronectin (FN) following exposure to e-cig aerosols and TS. Although our study examined the levels of 8-oxodG, CRP, and Fibronectin (FN), additional markers for lung injury need be explored in future studies [1] .
Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT02694198 Ain Shams Maternity Hospital
Medical; Abortion, Fetus
September 2015
NCT00371046 Thomas Jefferson University
Preterm Birth
October 2003 Not Applicable
NCT02021539 Centre Hospitalier Universitaire de N?mes
Obstetric Labor|Labor Onset|Obstetric Labor, Premature
February 2014

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)


Solvent & Solubility

In Vitro:

H 2 O : 8.33 mg/mL (ultrasonic and adjust pH to 7 with NaOH)



Synonyms

Fibronectins
Fibronectins, complexes
Fibronectin
Globulins, fibronectin
FN1
Protein FN1
Fn1 proteins
Fn1 protein
Cold insoluble globulin
Lets proteins
Lets protein

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