[CAS NO. 87-33-2]??Isosorbide dinitrate
PRODUCTS SPECIFICATIONS [87-33-2]
DESCRIPTION [87-33-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 236.14 |
| Molecular Formula | C6H8N2O8 |
| SMILES | [H][C@]12OC[C@H](O[N+]([O-])=O)[C@]1(OC[C@H]2O[N+]([O-])=O)[H] |
Summary
Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) [1] .
In Vivo
Isosorbide dinitrate (3 mg/kg; intratracheal; for 13 days) improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction
[1]
.
Isosorbide dinitrate postconditioning exhibits a cardioprotective effect against rat myocardial ischemia-reperfusion injury in vivo
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 5–6 weeks old male juvenile Sprague-Dawley rats (200–250 g) [1] |
| Dosage: | 3 mg/kg |
| Administration: | Intratracheal; for 13 days following coronary ligation |
| Result: | Reduced MI size and alleviated left and right ventricular remodeling following MI. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01030367 | Julius-Maximilians University |
Coronary Artery Disease
|
January 2007 | Not Applicable |
| NCT00827736 | Onze Lieve Vrouwe Gasthuis |
Anal Fissure
|
June 2002 | Phase 4 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 250 mg/mL ( 1058.69 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.2348 mL | 21.1739 mL | 42.3478 mL |
| 5 mM | 0.8470 mL | 4.2348 mL | 8.4696 mL |
| 10 mM | 0.4235 mL | 2.1174 mL | 4.2348 mL |
References
- [1] Wang X , et al. Intratracheal administration of isosorbide dinitrate improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction. Exp Ther Med. 2017 Aug;14(2):1399-1408.
- [2] Zhao X, et al. Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo. Med Sci Monit. 2019 Mar 2;25:1629-1636.
Synonyms