[CAS NO. 922731-01-9]??Omeprazole-d3
PRODUCTS SPECIFICATIONS [922731-01-9]
DESCRIPTION [922731-01-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 348.43 |
| Molecular Formula | C17H16D3N3O3S |
| SMILES | CC(C(OC)=C(C)C=N1)=C1CS(C2=NC3=CC=C(OC([2H])([2H])[2H])C=C3N2)=O |
Summary
Omeprazole-d3 (H 16868-d3) is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K i of 2 to 6 μM [1] . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 358.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8700 mL | 14.3501 mL | 28.7002 mL |
| 5 mM | 0.5740 mL | 2.8700 mL | 5.7400 mL |
| 10 mM | 0.2870 mL | 1.4350 mL | 2.8700 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution
References
- [1] Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.
- [2] Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.