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Product Name:ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

IUPAC Name:ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

: CAS：851443-04-4; Molecular Formula：C24H32FN3O6S; Purity：95%

: Catalog Number：CM128418; Molecular Weight：509.59

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: CAS NO:851443-04-4; Molecular Formula:C24H32FN3O6S; Melting Point:-; Smiles Code:O=C(OCC)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2; Density:

: Catalog Number:CM128418; Molecular Weight:509.59; Boiling Point:699.1°C at 760 mmHg; MDL No:MFCD12756003; Storage:Store at 2-8°C.

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: Pyrimidines; Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

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Product Overview	Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a medication prescribed by physicians to treat high cholesterol levels. It is a member of the statin class of drugs, which are used to reduce cholesterol levels by blocking the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the body. It is also used to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is the generic name for the drug Crestor, which is manufactured by AstraZeneca.
Physical Properties	Appearance: Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a off-white to pale beige solid. Solubility: The compound is slightly soluble in DMSO and methanol.
Chemical Properties	Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is an intermediate in the production of super statin Resuvastatin calcium.
Synthesis and Application	Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has been studied extensively in clinical trials, and has been found to reduce LDL cholesterol levels, as well as total cholesterol levels. Additionally, it has been shown to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has also been studied in the laboratory setting, and has been found to have a number of beneficial effects on various biochemical and physiological processes.

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