Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
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Pyridine?is a?basic?heterocyclic?organic compound?with the?chemical formula?C5H5N. It is structurally related to?benzene, with one?methine group?(=CH?)?replaced by a?nitrogen?atom. It is a highly flammable, weakly?alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.
Cyclohexane is an organic compound with a chemical formula C6H12. It is a colorless liquid with a pungent odor, insoluble in water, and soluble in most organic solvents such as ethanol, ether, benzene, and acetone. Cyclohexyl fragments are a common structure in both natural and synthetic drugs. It can be used as both core structure and part of achiral side chain.
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