GS-441524
GS-441524 是一種具有藥理活性的三磷酸核苷分子的分子前體，是貓傳染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制劑，其EC50值為0.78 μM。
GS-441524 Chemical Structure
CAS: 1191237-69-0
產(chǎn)品質(zhì)控
批次：
純度：
99.88%
99.88
GS-441524相關(guān)產(chǎn)品
| 相關(guān)產(chǎn)品 | Moroxydine HCl Aloperine Oleanolic Acid Harringtonine NGI-1 U-18666A LL-37 acetate Aloin B Lanatoside C Saikosaponin B2 Lapachol DTNB | 點擊展開 |
|---|---|---|
| 相關(guān)化合物庫 | 抗感染化合物庫 抗生素化合物庫 抗病毒化合物庫 抗寄生蟲藥物庫 腸道微生物代謝物庫 | 點擊展開 |
細胞實驗數(shù)據(jù)示例
| 細胞系 | 實驗類型 | 給藥濃度 | 孵育時間 | 活性描述 | 文獻信息(PMID) |
|---|---|---|---|---|---|
| HuH7 | Function assay | 10 uM | 24 hrs | Cmax in human HuH7 cells assessed as triphosphate concentration per million cells at 10 uM incubated for 24 hrs measured after washout by LC-MS analysis, Cmax=0.0000176μM | 22446091 |
| Vero | Antiviral assay | 24 hrs | Antiviral activity against Parainfluenza 3 C 243 infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=1.71μM | 22446091 | |
| Vero | Antiviral assay | 24 hrs | Antiviral activity against SARS coronavirus Toronto-2 infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=2.24μM | 22446091 | |
| HuH7 | Antiviral assay | 24 hrs | Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=4.1μM | 22446091 | |
| Vero E6 | Antiviral assay | 24 hrs | Antiviral activity against Dengue virus type 2 New Guinea C infected in african green monkey Vero E6 cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=9.46μM | 22446091 | |
| HeLa | Antiviral assay | 24 hrs | Antiviral activity against Yellow fever virus 17D infected in human HeLa cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=11μM | 22446091 | |
| MDCK | Antiviral assay | 24 hrs | Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=27.9μM | 22446091 | |
| Hep2 | Antiviral assay | 4 days | Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay, EC50=0.53μM | 28124907 | |
| HMVEC | Antiviral assay | 3 to 4 days | Antiviral activity against GFP-fused Ebolavirus infected in TERT-immortalized HMVEC assessed as reduction in viral replication preincubated with cells followed by viral infection measured after 3 to 4 days by fluorescence assay, EC50=0.78μM | 28124907 | |
| HuH7 | Antiviral assay | 3 days | Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells preincubated with cells for 3 days followed by viral infection by luciferase assay, EC50=4.1μM | 28124907 | |
| HuH7 | Antiviral assay | 3 days | Antiviral activity against Ebolavirus infected in human HuH7 cells after 3 days by end point dilution assay, EC50=1.5μM | 28792763 | |
| 點擊查看更多細胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | GS-441524 是一種具有藥理活性的三磷酸核苷分子的分子前體，是貓傳染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制劑，其EC50值為0.78 μM。 | ||
|---|---|---|---|
| 靶點 |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05996744 | Terminated | COVID-19 |
Gilead Sciences |
December 26 2023 | Phase 2|Phase 3 |
| NCT05715528 | Completed | COVID-19 |
Gilead Sciences |
February 8 2023 | Phase 3 |
| NCT05603143 | Terminated | COVID-19 |
Gilead Sciences |
November 5 2022 | Phase 3 |
| NCT04582266 | Completed | COVID-19 |
National Institute of Allergy and Infectious Diseases (NIAID)|Gilead Sciences |
March 31 2021 | -- |
| NCT04859244 | Completed | COVID-19 |
Copycat Sciences LLC |
January 1 2021 | Phase 1 |
| NCT04539262 | Completed | COVID-19 |
Gilead Sciences |
September 14 2020 | Phase 1|Phase 2 |
|
化學(xué)信息&溶解度
| 分子量 | 291.26 | 分子式 | C12H13N5O4 |
| CAS號 | 1191237-69-0 | SDF | -- |
| Smiles | C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N | ||
| 儲存條件(自收到貨起) | 3年 -20°C 粉狀 | ||
|
體外溶解度 |
DMSO : 58 mg/mL ( (199.13 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) Water : Insoluble Ethanol : Insoluble |
摩爾濃度計算器 |
|
體內(nèi)溶解配方 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內(nèi)配方計算器 | |||||
實驗計算
動物體內(nèi)配方計算器（澄清溶液）
第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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