Curcumin analog C1

別名: Curcumin analog Compound C1, TFEB activator 1 中文名稱：姜黃素類似物C1

目錄號(hào)：S6769 Purity: 99.74%

Curcumin analog C1 (Curcumin analog Compound C1)是有效的 transcription factor EB (TFEB) 激活劑，有望用于預(yù)防或治療阿爾茨海默氏病。

Curcumin analog C1 Chemical Structure

CAS: 39777-61-2

規(guī)格	價(jià)格	庫(kù)存
10mM (1mL in DMSO)	958.23	現(xiàn)貨
5mg	794.43	現(xiàn)貨
25mg	2432.43	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.74%

99.74

Curcumin analog C1相關(guān)產(chǎn)品

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生物活性

產(chǎn)品描述

Curcumin analog C1 (Curcumin analog Compound C1)是有效的 transcription factor EB (TFEB) 激活劑，有望用于預(yù)防或治療阿爾茨海默氏病。

靶點(diǎn)

TFEB

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06371417	Not yet recruiting	Antiphospholipid Syndrome (APS)\|Bullous Pemphigoid (BP)\|Beh?et''s Syndrome (BS)\|Dermatomyositis (DM)\|Immune-mediated Necrotizing Myopathy (IMNM)\|Immune Thrombocytopenia (ITP)	Chugai Pharmaceutical	May 31 2024	Phase 1
NCT06361238	Not yet recruiting	Delirium Postoperative	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	April 30 2024	Phase 3
NCT06178120	Recruiting	X-linked Adrenoleukodystrophy	Minoryx Therapeutics S.L.	January 2 2024	--
NCT06317467	Recruiting	Pre-Eclampsia	IRCCS Burlo Garofolo	September 13 2023	--
NCT05578417	Recruiting	Hereditary Angioedema (HAE)\|Angioedema	Takeda	June 15 2023	--
NCT05833620	Not yet recruiting	Hereditary Angioedema With C1 Esterase Inhibitor Deficiency	Hospital Universitari Vall d''Hebron Research Institute\|Hospital Universitario La Paz	May 2023	--

參考文獻(xiàn)
[1]https://www.ncbi.nlm.nih.gov/pubmed/?term=31858697 [2]https://pubmed.ncbi.nlm.nih.gov/27172265/

參考文獻(xiàn)

[1]https://www.ncbi.nlm.nih.gov/pubmed/?term=31858697
[2]https://pubmed.ncbi.nlm.nih.gov/27172265/

化學(xué)信息&溶解度

分子量	294.34	分子式	C₁₉H₁₈O₃
CAS號(hào)	39777-61-2	SDF	--
Smiles	COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC
儲(chǔ)存條件(自收到貨起)	3年 -20°C 粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年 -20°C 粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 30 mg/mL ( (101.92 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 2 mg/mL (6.79 mM)

Water : Insoluble

DMSO : 59 mg/mL ( (200.44 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 3 mg/mL (10.19 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方批次：現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑				動(dòng)物體內(nèi)配方計(jì)算器
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。
澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O 該配方已經(jīng)過Selleck實(shí)驗(yàn)室實(shí)測(cè)。如果上述溶解方案不能滿足您的需求，可聯(lián)系Selleck銷售提供定制化測(cè)試。	1.500mg/ml (5.10mM)	以 1 mL 工作液為例，取50μL30mg/ml的澄清DMSO儲(chǔ)備液加到400μL PEG300中，混合均勻使其澄清；向上述體系中加入50μLTween80，混合均勻使其澄清；然后繼續(xù)加入500μL ddH2O定容至 1 mL。工作液請(qǐng)現(xiàn)配現(xiàn)用！
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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操作手冊(cè)

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* 必填項(xiàng)

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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