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  2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP17-IN-1

CYP17-IN-1 (compound 9c) 是一種有效的，具有口服活性的 CYP17 的抑制劑，對(duì)大鼠和人 CYP17 的 IC50 值為 15.8 和 20.1 nM。

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CYP17-IN-1

CYP17-IN-1 Chemical Structure

CAS No. : 2093317-51-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2207
1 - 2 周
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

IC50 & Target

IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
20.1 nM
Compound: 9c
Inhibition of recombinant human CYP17 expressed in human A549 cell membranes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mins followed by substrate and cofactor addition after 60 mins by LC/MS analysis
Inhibition of recombinant human CYP17 expressed in human A549 cell membranes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mins followed by substrate and cofactor addition after 60 mins by LC/MS analysis
[PMID: 28350999]
體外研究
(In Vitro)

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 μM against CYP3A4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

312.40

Formula

C18H17FN2S
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
CYP17-IN-1
目錄號(hào)：
HY-101516
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