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  2. GPCR/G Protein Cell Cycle/DNA Damage
  3. Prostaglandin Receptor PERK
  4. ONO-8130

ONO-8130 是一種口服有效和選擇性的前列腺素 EP1 受體 (EP1 receptor) 拮抗劑。ONO-8130 可阻斷 L6 脊髓中 ERK 的磷酸化。ONO-8130 可減輕環(huán)磷酰胺致膀胱炎小鼠的膀胱疼痛。ONO-8130 可用于間質(zhì)性膀胱炎的研究。

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ONO-8130

ONO-8130 Chemical Structure

CAS No. : 459841-96-4

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2662
1 - 2 周
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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查看 Prostaglandin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

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  • 參考文獻(xiàn)

生物活性

ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].

體內(nèi)研究
(In Vivo)

ONO-8130 (0.3-30 mg/kg; Oral preadministration, once) strongly prevents both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner[1].
ONO-8130 (30 mg/kg; Orally, once) reverses the established cystitis-related bladder pain[1].
ONO-8130 (30 mg/kg; Orally, once) strongly inhibits phosphorylation of ERK in MDH, DCM, and SPN of the L6 spinal cord caused by intravesical administration of PGE2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ddY mice (18-22 g, 4-5 weeks old)[1]
Dosage: 0.3, 3, 10, and 30 mg/kg
Administration: Orally, once
Result: Strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.
Animal Model: Female ddY mice (18-22 g, 4-5 weeks old, established bladder pain caused by IP cyclophosphamide)[1]
Dosage: 10, 30 mg/kg
Administration: Orally, once (administered 2.75 hours after i.p. cyclophosphamide)
Result: Markedly attenuated the bladder pain-like nociceptive behavior and referred hyperalgesia in the acute phase (3.5-4 h after cyclophosphamide).
Animal Model: Female ddY mice (18-22 g, 4-5 weeks old, established bladder pain caused by IP cyclophosphamide)[1]
Dosage: 30 mg/kg
Administration: Orally, once (administered 4.75 hours after i.p. cyclophosphamide)
Result: Significantly suppressed the bladder pain-like nociceptive behavior and tended to reduce the referred hyperalgesia in the persistent phase, 5.5-6 hours after cyclophosphamide.
Animal Model: Female ddY mice (18-22 g, 4-5 weeks old, intravesical administration of PGE2 at 5 nmol/mouse)[1]
Dosage: 30 mg/kg
Administration: Orally, once
Result: Strongly inhibited phosphorylation of ERK in MDH, DCM, and SPN of the L6 spinal cord caused by intravesical administration of PGE2 at 5 nmol/mouse, exerted complete blockade in DCM, while its inhibitory effects in MDH and SPN were partial.
分子量

500.63

Formula

C25H28N2O5S2
CAS 號
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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產(chǎn)品名稱：
ONO-8130
目錄號：
HY-110198
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