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  2. Epigenetics
  3. Epigenetic Reader Domain
  4. MS31

MS31 是一種高親和性，高選擇性，片段樣的甲基賴氨酸讀寫蛋白 spindlin 1 (SPIN1) 抑制劑，有效破壞 SPIN1 與 H3K4me3 蛋白互相作用 (IC50=77 nM，AlphaLISA；243 nM，FP). MS31 選擇性結(jié)合 SPIN1 的 Tudor 結(jié)構(gòu)域 II (Kd=91 nM)。MS31 能有效抑制含三甲基賴氨酸肽與 SPIN1 的結(jié)合，對非腫瘤性細(xì)胞無毒。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 MS31 trihydrochloride 通常具有更好的水溶性和穩(wěn)定性。

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MS31

MS31 Chemical Structure

CAS No. : 2366264-12-0

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MS31 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of MS31:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells[1].

IC50 & Target

IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
U2OS IC50
3.2 μM
Compound: 3; MS31
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
[PMID: 31260300]
體外研究
(In Vitro)

MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

341.45

Formula

C20H27N3O2
CAS 號
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • 稀釋計(jì)算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
MS31
目錄號：
HY-125837
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