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  2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FGFR Apoptosis
  4. Infigratinib

Infigratinib  (Synonyms: BGJ-398; NVP-BGJ398)

目錄號: HY-13311
一鍵復制產品信息 純度: 99.82%
COA 產品使用指南 技術支持

Infigratinib (BGJ-398; NVP-BGJ398) 是 FGFR 家族的有效抑制劑，抑制 FGFR1，FGFR2，FGFR3 和 FGFR4 的 IC50 分別為 0.9 nM，1.4 nM，1 nM，60 nM。

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CAS No. : 872511-34-7

1.  客戶無需承擔相應的運輸費用。

2.  同一機構（單位）同一產品試用裝僅限申領一次，同一機構（單位）一年內

     可免費申領三個不同產品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數量
10 mM * 1 mL in DMSO ￥617
In-stock
5 mg ￥500
In-stock
10 mg ￥600
In-stock
25 mg ￥960
In-stock
50 mg ￥1200
In-stock
100 mg ￥1950
In-stock
200 mg ￥3200
In-stock
500 mg ￥5650
In-stock
1 g 現貨 詢價
5 g   詢價  
10 g   詢價  

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Customer Review

Other Forms of Infigratinib:

MCE 顧客使用本產品發(fā)表的 47 篇科研文獻

WB
Flow Cytometry
RT-PCR
IF
In Vivo Efficacy Study

    Infigratinib purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Jul 2;16(1):485.  [Abstract]

    BGJ398 (0-80 nM; 48 h). RT4 cells were treated with vehicle control or the indicated concentrations of BGJ398 in the presence or absence of interferon (IFN)-γ (10?ng/ml) for 48?h and subjected to western blot analysis.

    Infigratinib purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Jul 2;16(1):485.  [Abstract]

    RT-112 cells were exposed to IFN-γ (10?ng/ml) with or without L145 (2?μM) or BGJ398 (0.08?μM) for 48?h, stained with αPD-L1 antibody, and subjected to flow cytometry analysis.

    Infigratinib purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Jul 2;16(1):485.  [Abstract]

    BGJ398 (0.04?μM; 6-48 h). RT-112 cells were treated with vehicle control (CTRL) or IFN-γ (10?ng/ml) with or without L145 (1?μM) or BGJ398 (0.04?μM) for the indicated times, and subjected to RT-qPCR analyses.

    Infigratinib purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Jul 2;16(1):485.  [Abstract]

    RT-112 cells were treated with interferon (IFN)-γ (10?ng/ml) alone or in combination with L145 (1?μM) or BGJ398 (0.08?μM) for 24?h and subjected to immunofluorescence staining with antibodies against PD-L1 (green) and LC3B (red).

    Infigratinib purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2021 Aug 27;40(1):273.  [Abstract]

    BGJ398 (10 nM; 24 h). Western blotting was performed to examine the effect of cyclin G2 on Y10 phosphorylation of LDHA in the presence or absence of BGJ398.

    Infigratinib purchased from MCE. Usage Cited in: Cancer Discov. 2018 Mar;8(3):354-369.  [Abstract]

    BGJ398 (30-50 mg/kg; oral). In vivo dosing of BGJ398 at 30mg/kg achieves target inhibition measured by pFrs2 and pErk levels.

    Infigratinib purchased from MCE. Usage Cited in: Cancer Discov. 2018 Mar;8(3):354-369.  [Abstract]

    BGJ398 (30-50 mg/kg; oral). Combining BGJ398 and a different PARP-inhibitor, BMN673, induces sustained tumor remission.

    • 生物活性

    • 實驗參考方法

    • 純度 & 產品資料

    • 參考文獻

    生物活性

    Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

    IC50 & Target[1]

    FGFR1

    0.9 nM (IC50)

    FGFR2

    1.4 nM (IC50)

    FGFR3

    1 nM (IC50)

    FGFR4

    60 nM (IC50)

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    AN3-CA GI50
    0.039 μM
    Compound: 1
    Antiproliferative activity against human AN3-CA cells harboring FGFR2 K310R/N549K mutant assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against human AN3-CA cells harboring FGFR2 K310R/N549K mutant assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 GI50
    0.005 μM
    Compound: 1
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3 assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3 assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 GI50
    2.605 μM
    Compound: 1
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3-V555M mutant assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3-V555M mutant assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 GI50
    4.005 μM
    Compound: 1
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 V550E mutant assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 V550E mutant assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 GI50
    > 5 μM
    Compound: 1
    Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 GI50
    > 5 μM
    Compound: 1
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 N535K mutant assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 N535K mutant assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
    BaF3 IC50
    132.6 nM
    Compound: 2;BGJ-398
    Antiproliferative activity against mouse BAF3 cells expressing TEL-fused FGFR4 kinase after 72 hrs by CCK8 or MTT assay
    Antiproliferative activity against mouse BAF3 cells expressing TEL-fused FGFR4 kinase after 72 hrs by CCK8 or MTT assay
    		[PMID: 29522671]
    BaF3 IC50
    3343.8 nM
    Compound: 2;BGJ-398
    Antiproliferative activity against mouse BAF3 cells expressing TEL-fused KDR kinase after 72 hrs by CCK8 or MTT assay
    Antiproliferative activity against mouse BAF3 cells expressing TEL-fused KDR kinase after 72 hrs by CCK8 or MTT assay
    		[PMID: 29522671]
    Hep 3B2 IC50
    85 nM
    Compound: Infigratinib
    Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability by cell proliferation assay
    Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability by cell proliferation assay
    		[PMID: 32930584]
    Huh-7 IC50
    57.2 nM
    Compound: 2;BGJ-398
    Antiproliferative activity against FGF19/FGFR4 expressing human HuH7 cells after 72 hrs by CCK8 or MTT assay
    Antiproliferative activity against FGF19/FGFR4 expressing human HuH7 cells after 72 hrs by CCK8 or MTT assay
    		[PMID: 29522671]
    Huh-7 IC50
    80 nM
    Compound: Infigratinib
    Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay
    Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay
    		[PMID: 32930584]
    J82 GI50
    3.345 μM
    Compound: 1
    Antiproliferative activity against human J82 cells harboring FGFR3 K652E mutant assessed as cell growth inhibition by CellTiter-Glo assay
    Antiproliferative activity against human J82 cells harboring FGFR3 K652E mutant assessed as cell growth inhibition by CellTiter-Glo assay
    		[PMID: 35436119]
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