Telmisartan-¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

1. 該化合物可作為示蹤劑。
2. 該化合物可作為 NMR、GC-MS 或 LC-MS 分析中的內(nèi)標品，用于定量分析。

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[55].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

518.63

C₃₂¹³CH₂₇D₃N₄O₂

1261396-33-1

144701-48-4

替米沙坦 d₄-¹³C,d₃

Room temperature in continental US; may vary elsewhere.

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  [5]. Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69(2):358-364.  [Content Brief]

  [6]. Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8(5):8536-8549.  [Content Brief]