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  2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  3. RAR/RXR Cytochrome P450 Autophagy
  4. Talarozole

Talarozole (R115866) 是一種口服性全反式維甲酸代謝阻斷劑 (RAMBA)，可提高內(nèi)源性全反式維甲酸 (RA) 的細(xì)胞內(nèi)水平。Talarozole 抑制 CYP26A1 和 CYP26B1，IC50 值分別為 5.4 和 0.46 nM。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

CAS No. : 201410-53-9

1.  客戶無需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1430
In-stock
1 mg ￥621
In-stock
2 mg ￥900
In-stock
5 mg ￥1300
In-stock
10 mg ￥1800
In-stock
25 mg ￥3025
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50 mg ￥4200
In-stock
100 mg ￥5900
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Talarozole:

    Talarozole purchased from MCE. Usage Cited in: PLoS Genet. 2017 Dec 11;13(12):e1007112.  [Abstract]

    Embryos raised in media containing 0.01% DMSO develop normally. 100% of embryos treated with Talarozole between 54 and 60 hpf displayed ectopic muscle projection in the second pharyngeal arch, and the intermandibularis posterior muscles overextended in 58.3% of embryos (n=64).

    Talarozole purchased from MCE. Usage Cited in: J Exp Zool B Mol Dev Evol. 2017 Sep;328(6):575-586.  [Abstract]

    Effect of R115866 on COL9A1 expression. R115866 enhances the effect of ATRA on COL9A1 expression. R115866 (1 μM) is dissolved in DMSO. Control receive the vehicle only.

    Talarozole purchased from MCE. Usage Cited in: University of Texas. August 2017.

    100% of embryos treated with Talarozole between 54 and 60 hpf displayed ectopic muscle projection in the second pharyngeal arch, and the intermandibularis posterior muscles overextended in 58.3% of embryos (n = 64).

    Talarozole purchased from MCE. Usage Cited in: Mol Pharmacol. 2016 May;89(5):560-74.  [Abstract]

    Induction of hepatic mitochondrial biogenesis genes in mice after Talarozole (TLZ) treatment compared with vehicle-treated mice. All mRNA data are presented as fold change in mRNA abundance relative to control mice. β-Actin is used as the housekeeping gene. For protein data, results are expressed as ratio of SDHA to β-actin.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.

    IC50 & Target

    CYP26

     

    細(xì)胞效力
    (Cellular Effect)
    <深水埗区| 若尔盖县| 镇安县| 凌云县| 比如县| 九江县| 黔西县| 马鞍山市| 东城区| 正阳县| 东乡| 宁晋县| 米易县| 安乡县| 正安县| 文安县| 蓝田县| 湾仔区| 南郑县| 桂东县| 靖宇县| 阿拉善左旗| 含山县| 普格县| 靖西县| 乌兰县| 吴忠市| 永城市| 东光县| 湾仔区| 永城市| 云南省| 广汉市| 惠东县| 台北县| 阿拉善右旗| 德江县| 民乐县| 饶阳县| 邹城市| 富源县|
    Cell Line Type Value Description References
    Sf9 IC50
    0.00046 μM
    Compound: 3; R115866
    Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
    Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
    		[PMID: 26918322]