4 | 1795027-71-2 | TSE-424-d4 | 巴多昔芬-d4 | Estrogen Receptor/ERR | Inhibitor | inhibitor | inhibit"/>

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  2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Bazedoxifene-d4 acetate

Bazedoxifene-d4 (acetate) 是 Bazedoxifene 的氘代物。 Bazedoxifene (TSE-424) 是一種有口服活性的，能透過血腦屏障的，非甾體、選擇性的雌激素受體調節(jié)劑 (SERM)，對 ERα 和 ERβ 作用的 IC50 值分別為 26 nM 和 99 nM，可用于骨質疏松癥的研究。Bazedoxifene 也是一種 IL-6/GP130 蛋白相互作用抑制劑，可用于胰腺癌的研究。

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Bazedoxifene-d<sub>4</sub> acetate

Bazedoxifene-d4 acetate Chemical Structure

CAS No. : 1795027-71-2

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規(guī)格 價格 是否有貨
1 mg ￥5800
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Other Forms of Bazedoxifene-d4 acetate:

查看 Estrogen Receptor/ERR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Bazedoxifene-d4 (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

產(chǎn)品應用

1. 該化合物可作為示蹤劑。
2. 該化合物可作為 NMR、GC-MS 或 LC-MS 分析中的內標品，用于定量分析。
體外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

534.68

Formula

C32H34D4N2O5
CAS 號
非標記 CAS
中文名稱

巴多昔芬-d4
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Bazedoxifene-d4 acetate
目錄號：
HY-A0031S2
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