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  2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Cyclizine dihydrochloride

Cyclizine dihydrochloride，一種哌嗪衍生物，是一種有效的選擇性組胺 H1 受體拮抗劑。Cyclizine dihydrochloride 可用于惡心、嘔吐和頭暈的研究。

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Cyclizine dihydrochloride

Cyclizine dihydrochloride Chemical Structure

CAS No. : 5897-18-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥388
1-2 周
10 mg ￥584
1-2 周
25 mg ￥1168
1-2 周
50 mg ￥1753
1-2 周
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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Customer Review

Other Forms of Cyclizine dihydrochloride:

查看 Histamine Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness[1][2][3].

IC50 & Target[1]

H1 Receptor

 

體外研究
(In Vitro)

Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants[1].
Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive male CDI mice (Charles River) weighing 25-30 g[3]
Dosage: 1, 10 mg/kg
Administration: s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.
Result: Enhanced locomotor activity in a dose-dependent manner.
分子量

339.30

Formula

C18H24Cl2N2
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Cyclizine dihydrochloride
目錄號(hào)：
HY-B1397A
需求量：
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