TRAP-14

SKU: orb3053977

Description

Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.

Images & Validation

Key Properties

CAS Number	137339-65-2
MW	1739.96
Purity	>98% (HPLC)
Formula	C₈₁H₁₁₈N₂₀O₂₃
Solubility	H2O : ≥ 100 mg/mL (57.47 mM)

Bioactivity

In Vitro	Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin. Read more...

In Vitro

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

Storage & Handling

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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TRAP-14 (orb3053977)

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Purity:	≥95%
CAS Number:	137339-65-2
MW:	1739.96
Formula:	C₈₁H₁₁₈N₂₀O₂₃

Purity:	> 95%
MW:	1738.98
Source:	Synthetic

Purity:	≥95%
MW:	1739.96

Purity:	≥95%
MW:	1738.98

TRAP-14

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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TRAP-14 (orb3053977)

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