DL-Menthol is a synthetic or naturally derived compound from mint oils, known for its cooling flavor and local anesthetic properties. It is widely used in research as a TRPM8 channel agonist for studying thermosensation, pain, and inflammation in both in vitro and in vivo models.
Research Area
Metabolism Research, Pharmacology & Drug Discovery
Images & Validation
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Key Properties
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CAS Number
1490-04-6
MW
156.26
Purity
99.88% (May vary between batches)
Formula
C10H20O
SMILES
CC(C)C1CCC(C)CC1O
Target
Calcium Channel
Solubility
DMSO:50 mg/mL (319.98 mM)
Bioactivity
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In Vivo
High levels of the major DL-Menthol metabolite, menthol-glucuronide, was observed in the urine of smokers of either menthol or non-menthol cigarettes. The fact that a significant inverse correlation was observed between the levels of urinary menthol-glucuronide and NNAL-N-glucuronide, a major detoxification metabolite of the tobacco carcinogen, NNK, suggests that menthol may be inhibiting the clearance of this important tobacco carcinogen.
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