NECA

SKU: orb1220445

Description

NECA is an agonist of Adenosine receptor increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.

Images & Validation

Key Properties

CAS Number	35920-39-9
MW	308.29
Purity	>98% (HPLC)
Formula	C₁₂H₁₆N₆O₄
SMILES	CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Target	AChR
Solubility	DMSO:150 mg/mL (486.55 mM)

Bioactivity

In Vivo	After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA): F(4, 12) = 14.9; P<0.001]. The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4, 12) = 16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats. Read more...

In Vivo

After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA): F(4, 12) = 14.9; P<0.001]. The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4, 12) = 16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats.

Storage & Handling

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

5'-N-Ethylcarboxamidoadenosine

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Gene Symbol

AChR

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NECA (orb1220445)

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Applications:	WB
Predicted Reactivity:	Canine, Equine, Guinea pig, Human, Rabbit, Rat
Reactivity:	Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	98.68%
CAS Number:	490-59-5
MW:	214.18
Formula:	C₁₀H₆N₄O₂

Purity:	98.95%
CAS Number:	35920-39-9
MW:	308.29
Formula:	C₁₂H₁₆N₆O₄

Purity:	95.72%
CAS Number:	380367-48-6
MW:	660.5
Formula:	C₃₃H₃₁BF₂N₄O₆S

CAS Number:	219982-12-4
MW:	640.75
Formula:	C₃₀H₄₀N₈O₆S

NECA

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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NECA (orb1220445)

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