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Kainic acid

SKU: orb1707144

Description

Kainic acid is a potent excitatory amino acid receptor agonist (EC50 = 16.2 μM) used to model excitotoxicity and induce seizures in neurological research. It is widely applied in both in vitro receptor studies and in vivo models of epilepsy and neurodegenerative diseases.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number487-79-6
MW213.2
Purity>98%
FormulaC10H15NO4 (xH2O)
SMILESCC(=C)[C@H]1CNC([C@H]1CC(O)=O)C(O)=O
TargetIon channel
SolubilitySoluble in Water (up to 10 mg/ml).

Bioactivity

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Target IC50
Glutamate receptor 6 (HEK293 cells):0.7 μM (EC50)|Glutamate receptor 5 (HEK293 cells):16.2 μM (EC50)|Neuron:17.3 μM (EC50)
In Vivo
METHODS: To study the effect of Kainic acid on epileptic seizures, Kainic acid (30 mg/kg) was intraperitoneally injected into juvenile (20 mg/kg) or adult (30 mg/kg) male Slack+/+ and Slack?/? mice. RESULTS: After injection of 30 mg/kg of Kainic acid, grade 3 or above epileptic seizures occurred in mice within 20 minutes. Different mouse strains have different sensitivities to Kainic acid. For example, Slack - / - mice are more prone to severe epileptic seizures and status epilepticus (SE), and have a higher mortality rate than Slack+/+ mice.
In Vitro
METHODS: After the NSC-34 mouse motor neuron cell line was treated with Kainic acid (0.1 mM, 0.5 mM, 1 mM) for 24 and 48 hours, the cell viability was detected by the MTT method. RESULTS: Kainic acid induced excitotoxic injury, with an IC50 value of approximately 0.5 mM.

Storage & Handling

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StorageRT
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Inhibitor, Kainic acid, inhibit

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Key Properties

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No computed properties available.

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Kainic acid (orb1707144)

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10 mg
$ 250.00
50 mg
$ 710.00
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