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5-hydroxytryptamine

SKU: orb1217957

Description

5-hydroxytryptamine is a natural product from animals.

Images & Validation

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Key Properties

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CAS Number50-67-9
MW176.22
Purity>98% (HPLC)
FormulaC10H12N2O
SMILESNCCc1c[nH]c(cc2)c1cc2O
TargetOthers
SolubilityIn Vitro: DMSO : 100 mg/mL (567.47 mM)

Bioactivity

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In Vivo
Serotonin produces robust hypersensitivity compared with saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/-mice receiving Serotonin compared with IL-13-/-receiving vehicle following induction of DSS colitis.
In Vitro
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modulation the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki = 44 μM). Results show that addition of 100 μM of Serotonin decreases the reaction velocity of COMT.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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5-hydroxytryptamine (orb1217957)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
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% Tween 80 +
%

Available Sizes

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200 mg
500 mg
5 mg
$ 620.00
10 mg
$ 900.00
25 mg
$ 1,420.00
50 mg
$ 1,920.00
100 mg
$ 2,570.00
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