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Norepinephrine

SKU: orb1300117

Description

Norepinephrine is a catecholamine neurotransmitter and potent agonist of α1, α2, and β1 adrenergic receptors. It is widely utilized in research as a vasopressor agent for modeling shock and cardiomyopathy, and is frequently applied in both in vitro receptor studies and in vivo physiological experiments.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number51-41-2
MW169.18
Purity99.84% (May vary between batches)
FormulaC8H11NO3
SMILES[C@@H](CN)(O)C1=CC(O)=C(O)C=C1
TargetAutophagy,MMP,Adrenergic Receptor,Endogenous Metabolite
SolubilityDMSO:8.46 mg/mL (50.01 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);0.1M HCl:10 mg/mL (59.11 mM);10% DMSO+90% Saline:0.1 mg/mL (0.59 mM)

Bioactivity

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Target IC50
α2A-adrenoceptor:56 nM (Ki)|α1-adrenoceptor:330 nM (Ki)|β1-adrenoceptor:740 nM (Ki)
In Vivo
METHODS: To test in vivo activity, Norepinephrine (0.2-2 mg/kga) was administered intraperitoneally to C57BL6/J mice fed a high-fat diet once daily for two weeks. RESULTS: A subset of Norepinephrine-treated mice developed unexpected adverse events, including bladder dilatation and decreased renal perfusion due to renal discoloration.
In Vitro
METHODS: Adult hippocampal cells were treated with Norepinephrine (0.1-10 μM) for 10-13 days and the number of neurospheres was determined using classical neurosphere assay. RESULTS: A significant increase in the number of neurospheres was obtained at 100 nm and in the presence of 1 μM Norepinephrine, and a twofold increase in the number of neurospheres was observed in the presence of 10 μM Norepinephrine. METHODS: Human pancreatic cancer cells BxPC-3 and Panc-1 were treated with Norepinephrine (10 μM) for 12-48 h. Cell viability was assayed by MTT Assay. RESULTS: Norepinephrine treatment alone significantly enhanced the viability of PDAC cells.

Storage & Handling

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Storage-20°C. Keep away from direct sunlight. Keep away from moisture, store under nitrogen. It is recommended to use nitrogen purging to isolate the compound from air for protection. If this is not feasible, it is advised to use the compound as soon as possible, store it sealed, and minimize its exposure time to air.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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β1-adrenoceptor, α2A-adrenoceptor, α1-adrenoceptor, inhibit, L-Noradrenaline, Norepinephrine, Nor-Epirenan, MMP-2, MMP-9, EndogenousMetabolite, Endogenous Metabolite, Inhibitor, Levonor, Levonoradrenaline, Levophed, Levarterenol, Arterenol, Autophagy, Aktamin, Adrenergic Receptor, AdrenergicReceptor, Beta Receptor

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Key Properties

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No computed properties available.

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Norepinephrine (orb1300117)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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50 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
100 mg
$ 90.00
500 mg
$ 130.00
1 g
$ 170.00
DispatchUsually dispatched within 3-5 working days
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