Ketogestin (11-Ketoprogesterone) is a synthetic progestin used in hormone research. It functions as a membrane glucocorticoid receptor agonist, an 11β-hydroxysteroid dehydrogenase inhibitor, and a weak GABAA receptor negative allosteric modulator. This compound is applied in studies of steroid metabolism, neuroendocrinology, and related in vitro and in vivo experimental models.