2-Arachidonoylglycerol (2-AG) is a full agonist of neuronal cannabinoid receptors. This endogenous endocannabinoid is a key research tool for studying synaptic plasticity, as it inhibits the induction of long-term potentiation at hippocampal CA3–CA1 synapses in both in vitro and in vivo models.
Research Area
Metabolism Research, Pharmacology & Drug Discovery
Images & Validation
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Key Properties
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CAS Number
53847-30-6
MW
378.55
Purity
95.00% (May vary between batches)
Formula
C23H38O4
SMILES
O(C(CO)CO)C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O
Target
Cannabinoid Receptor,Endogenous Metabolite
Solubility
DMSO:10 mg/mL (26.42 mM)
Bioactivity
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Target IC50
CB1:0.8?μM
In Vitro
2-Arachidonylglycerol (2-AG), a cannabinoid ligand obtained from intestinal tissue, functions as a full agonist in activating neuronal cannabinoid receptors. It impedes the development of long-term potentiation at CA3-CA1 synapses and, by binding to cannabinoid receptors, produces effects characteristic of cannabinoid drugs.
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