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Dermorphin

SKU: orb1220397

Description

Dermorphin is agonist of μ-opioid receptor (MOR) agonist.

Images & Validation

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Key Properties

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CAS Number77614-16-5
MW802.87
Purity>98% (HPLC)
FormulaC40H50N8O10
SMILESCC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CO)C(N)=O
TargetOpioid Receptor
SolubilityIn Vitro: H2O : 120 mg/mL (149.46 mM)

Bioactivity

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In Vitro
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
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$ 90.00
5 mg
$ 160.00
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100 mg
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