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DAMGO

SKU: orb1223053

Description

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.

Images & Validation

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Key Properties

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CAS Number78123-71-4
MW513.6
Purity>98% (HPLC)
FormulaC26H35N5O6
SMILESOc2ccc(C[C@H](N)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO)cc2
Targetp38 MAPK
SolubilityDMSO : 33.33 mg/mL. 64.90 mM;

Bioactivity

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In Vivo
DAMGO (i. v. , 0.5-2 mg/kg) can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect.
In Vitro
DAMGO (1-10 μM) significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression. DAMGO (1 μM) effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i. e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 130.00
10 mg
$ 220.00
25 mg
$ 430.00
50 mg
$ 640.00
100 mg
$ 930.00
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