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Salmeterol

SKU: orb1217520

Description

Salmeterol is a long-acting agonist of beta2-adrenergic receptor (beta 2AR) used for treatment ofasthma.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number89365-50-4
MW415.57
Purity>98% (HPLC)
FormulaC25H37NO4
SMILESOC1=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
TargetAdenosine Receptor
SolubilityDMSO:100 mg/mL (240.63 mM)

Bioactivity

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In Vivo
Animal model: Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g). Dosage: Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg). Administration: The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period. Result: COPD assessment test scores were markedly improved in mice with COPD.
In Vitro
Cell Proliferation Assay Cell line: Human T lymphocytes (THP-1 cells). Concentration: 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 μM Incubation time: Result: The proliferation of Th2 cells was inhibited in a concentration dependent manner.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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GR33343X

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Salmeterol (orb1217520)

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% Tween 80 +
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Available Sizes

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200 mg
500 mg
5 mg
$ 100.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 400.00
100 mg
$ 660.00
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