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Simvastatin (sodium salt)
Catalog No.
C4426
HMG-CoA reductase inhibitor
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Simvastatin (sodium salt) (CAS: 101314-97-0) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a critical enzyme controlling the rate-limiting step in cholesterol biosynthesis. It binds with high affinity to HMG-CoA reductase, exhibiting a Ki of approximately 0.12 nM. In hepatocyte-derived Hep G2 cells, simvastatin demonstrated potent suppression of cholesterol biosynthesis, reducing the incorporation of radiolabeled acetate into sterols (IC50 ≈15 nM). Animal studies with orally administered simvastatin indicated marked reduction in plasma cholesterol levels, validating its utility in experimental models exploring cholesterol regulation and lipid metabolism.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 460.59 |
| Cas No. | 101314-97-0 |
| Formula | C25H41NaO6 |
| Synonyms | Simvastatin hydroxy acid sodium |
| Solubility | ≥28.85 mg/mL in DMSO; ≥23.05 mg/mL in EtOH; ≥5.47 mg/mL in H2O with ultrasonic |
| Canonical SMILES | CCC(C)(C)C(O[C@@H]1[C@H]([C@@H](CC[C@H](C[C@H](CC([O-])=O)O)O)[C@@H](C)C=C2)C2=C[C@H](C)C1)=O.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
