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Oligomycin C

Catalog No.
C3410
mitochondrial F1FO-ATP synthase inhibitor
Grouped product items
SizePriceStock Qty
1mg
$545.00
Ship with 5-10 days
5mg
$1,635.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Oligomycins are the macrolide antibiotics produced by Streptomyces species such as Streptomyces diastatochromogenes, S. libani and S. avermitilis. Oligomycins exihibited a strong toxicity against other organisms, such as Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici. Oligomycins showed no activity towards bacteria. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism.

Oligomycin C is a minor antifungal compound isolated from Streptomyces strain in soil sample that acts as an inhibitor of the mitochondrial F1FO-ATP synthase [1]. Inhibition of the ATP synthase by oligomycins resulted in cell death [2].

References:
[1].? Yang P W, Li M G, Zhao J Y, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus[J]. Folia microbiologica, 2010, 55(1): 10-16.
[2].? Marton A, Mihalik R, Bratincsák A, et al. Apoptotic cell death induced by inhibitors of energy conservation[J]. European journal of biochemistry, 1997, 250(2): 467-475.

Chemical Properties

Physical AppearanceA white lyophilisate
StorageStore at -20°C
M.Wt775.1
Cas No.11052-72-5
FormulaC45H74O10
Synonyms12-deoxy Oligomycin A
SolubilitySoluble in DMSO
Chemical Name(1R,?2'R,?4E,?5'S,?6S,?6'S,?7R,?8S,?10R,?11S,?12S,?14S,?15S,?16R,?18E,?20E,?22R,?25S,?28S,?29R)?-22-?ethyl-?3',?4',?5',?6'-?tetrahydro-?7,?11,?15-?trihydroxy-?6'-?[(2R)?-?2-?hydroxypropyl]?-?5',?6,?8,?10,?12,?14,?16,?28,?29-?nonamethyl-spiro[2,?26-?dioxab
Canonical SMILESO=C([C@@H](C)[C@H](O)[C@@H](C)/C=C/1)[C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@@]2([H])[C@@H](C)[C@@]([C@H](C)[C@@]3(CC[C@H](C)[C@@](C[C@H](O)C)([H])O3)O2)([H])OC1=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Oligomycin C
 

User Guide

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