Vanillin
Vanillin is the primary chemical component in the extract of vanilla bean, which has been widely used as a flavorant in foods, beverages and tobacco due to its popular odor. Vanillin has multifunctional effects such as anti-sickling, antiangiogenetic, anti-colitis, antianalgesic and antioxidant effects. Thus, vanillin might be used as a potential agent for the treatment of sickle cell anemia and major depressive disorder, as well as an antagonizing compound to counteract the negative effects of ultraviolet A (UVA) irradiation on proliferative potential and stemness of human adipose tissue-derived mesenchymal stem cells (hAMSCs).?
References:
1.?Abraham DJ, Mehanna AS, Wireko FC, et al. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood, 1991, 77(6): 1334-1341.
2.?Lee SY, Park SH, Kim MO, et al. Vanillin attenuates negative effects of ultraviolet A on the stemness of human adipose tissue-derived mesenchymal stem cells. Food and Chemical Toxicology, 2016, 96: 62-69.
3. Xu J, Xu H, Liu Y, et al. Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain. Psychiatry Research, 2015, 225(3): 509-514.
| Storage | Store at -20°C |
| M.Wt | 152.15 |
| Cas No. | 121-33-5 |
| Formula | C8H8O3 |
| Solubility | insoluble in H2O; ≥31.1 mg/mL in DMSO; ≥41.3 mg/mL in EtOH |
| Canonical SMILES | COc(cc(C=O)cc1)c1O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
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Cell lines |
hAMSCs |
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Reaction Conditions |
1 ~ 100 μM vanillin for 3 d incubation |
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Applications |
Vanillin dose-dependently attenuated UVA-induced reduction of the proliferative potential and stemness of hAMSCs. At the tested concentrations, vanillin exhibited no apoptotic effects. In addition, the reduced expression levels of OCT4, NANOG and SOX2 caused by UVA irradiation were all increased by vanillin treatment. |
| Animal experiment:[3] | |
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Animal models |
A rat model of chronic depression |
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Dosage form |
5ml of 600 mg/l vanillin (in distilled water) Sprayed on to the floor, at 8 hourly intervals |
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Applications |
Vanillin could alleviate depressive symptoms in the rat model of chronic depression via the olfactory pathway. Moreover, vanillin elevated both serotonin and dopamine levels in brain tissue. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Abraham DJ, Mehanna AS, Wireko FC, et al. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood, 1991, 77(6): 1334-1341. 2. Lee SY, Park SH, Kim MO, et al. Vanillin attenuates negative effects of ultraviolet A on the stemness of human adipose tissue-derived mesenchymal stem cells. Food and Chemical Toxicology, 2016, 96: 62-69. 3. Xu J, Xu H, Liu Y, et al. Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain. Psychiatry Research, 2015, 225(3): 509-514. |
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Quality Control & MSDS
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Chemical structure
