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POM 1

Catalog No.
B7153
A potent Ecto-NTPDase inhibitor
Grouped product items
SizePriceStock Qty
50mg
$124.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

POM 1, also known as sodium polyoxotungstate and sodium metatungstate, is a novel, potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolases (Ecto-NTPDases). POM 1 exhibits minor selectivity for NTPDase 1 and NTPDase 3 over NTPDase 2, with Ki values being 2.58, 28.8 and 3.26 μM for NTPDase 1 (CD39), NTPDase 2 and NTPDase 3, respectively. Ecto-NTPDases capable of hydrolyzing nucleoside tri- and diphosphates are able to reduce the effective concentration of the released nucleotide, and inhibitors of Ecto-NTPDases can thus serve as valuable tools for amplifying the biological effects triggered by extracellularly released nucleotides.?

References:

1.?Müller CE, Iqbal J, Baqi Y, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, 16(23): 5943-5947.

2. Wall MJ, Wigmore G, Lopatár J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, 2008, 55(7): 1251-1258.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt2986.01
Cas No.12141-67-2
FormulaH2O40Na6W12
Solubility≥149.3 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥65.4 mg/mL in H2O
Canonical SMILES[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O.[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O-].[O-].[O-].[O-].[O-].[O-].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[2]

Cell lines

Cerebellar and hippocampal slices

Reaction Conditions

100 μM POM 1

Applications

POM 1 was more effective than ARL 67156 (the best available Ecto-NTPDase inhibitor) at blocking ATP breakdown, but its usefulness was limited by off-target actions on synaptic transmission.

Note

The technical data provided above is for reference only.

References:

1. Müller CE, Iqbal J, Baqi Y, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, 16(23): 5943-5947.

2. Wall MJ, Wigmore G, Lopatár J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, 2008, 55(7): 1251-1258.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

POM 1
 

User Guide

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