一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

AG-183

Catalog No.
C4844
inhibitor of epidermal growth factor (EGF) receptor kinase
Grouped product items
SizePriceStock Qty
10mg
$112.00
Ship with 5-10 days
25mg
$266.00
Ship with 5-10 days
50mg
$473.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

AG-183, a member of tyrphostin, is an inhibitor of protein tyrosine kinase [1].

Protein tyrosine kinase is an enzyme that catalyzes the transfer of the γ phosphate of ATP to tyrosine residues on protein substrates. Phosphorylation of proteins by kinases is an important mechanism in signal transduction and regulating cellular activity, such as cell division. Tyrosine phosphorylation is a key covalent modification that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. Phosphorylation of tyrosine residues modulates enzymatic activity and creates binding sites for the recruitment of downstream signaling proteins [2].

PTK inhibitors could preferentially inhibit the epidermal growth factor (EGF) receptor kinase to block EGF-dependent cell proliferation [1]. In the human epidermoid carcinoma cell line, A431AG-183 inhibited the activity of epidermal growth factor (EGF) receptor kinase with an IC50 value of 800 nM [1].

References:
[1] Gazit A, Yaish P, Gilon C, et al.  Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors[J]. Journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] Hubbard S R, Till J H.  Protein tyrosine kinase structure and function[J]. Annual review of biochemistry, 2000, 69(1): 373-398.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt268.2
Cas No.122520-90-5
FormulaC13H8N4O3
SynonymsTyrphostin 51
Solubility≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
Canonical SMILESNC(/C(\C#N)=C/c(cc1O)cc(O)c1O)=C(C#N)C#N
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

AG-183
 

User Guide

梁山县| 洛阳市| 运城市| 黑山县| 蓬溪县| 鄂温| 开原市| 德庆县| 宝鸡市| 永修县| 双辽市| 花莲市| 灵川县| 宁国市| 康保县| 南宁市| 洪湖市| 星子县| 哈巴河县| 叶城县| 商水县| 翁牛特旗| 谢通门县| 三门县| 舟曲县| 孝义市| 镇沅| 南京市| 莒南县| 临洮县| 万盛区| 囊谦县| 九龙城区| 漳州市| 邹城市| 宝兴县| 麟游县| 安顺市| 铜梁县| 京山县| 怀宁县|