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ML-264

Catalog No.
C3474
Krüppel-like factor 5 (KLF5) inhibitor
Grouped product items
SizePriceStock Qty
5mg
$100.00
In stock
10mg
$162.00
In stock
25mg
$340.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

ML-264 (CAS 1550008-55-3) is a selective small molecule inhibitor targeting Krüppel-like factor 5 (KLF5), a transcription factor that facilitates proliferation in intestinal epithelial cells and is implicated in colorectal cancer progression. Mechanistically, ML-264 suppresses KLF5 expression and disrupts downstream MAPK signaling by reducing EGR1 levels, a transcriptional activator of KLF5. In cell-based assays, ML-264 shows potent antiproliferative activity against colorectal cancer lines (DLD-1 IC50: 29 nM; HT29 and SW620 IC50: 130 nM), sparing non-cancerous IEC-6 cells. In vivo, ML-264 inhibits tumor growth in colorectal cancer xenograft models, highlighting its relevance as a research tool in cancer biology.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt384.9
Cas No.1550008-55-3
FormulaC17H21ClN2O4S
Solubility≥48.6 mg/mL in DMSO; ≥2.34 mg/mL in EtOH with gentle warming and ultrasonic; insoluble in H2O
Chemical Name(2E)-3-(3-chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-2-propenamide
Canonical SMILESCN(C(CC1)CCS1(=O)=O)C(CNC(/C=C/c1cccc(Cl)c1)=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

ML-264
 

User Guide

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