一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

Ryanodine

Catalog No.
B5092
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum
Grouped product items
SizePriceStock Qty
1mg
$546.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ryanodine is a selective ryanodine receptor (RyR) blocker, with IC50 value of 10 nM [1].?

RyR, expressed on the sarcoplasmic reticulum membranes of excitable cells, including smooth muscle myocytes, is important to the regulation of pulmonary as well as systemic vascular tone. Opening of clusters of RyRs gives rise to Ca2+ spark events which are particularly important for activation of the large-conductance Ca2+ and voltage-activated K+ channel in vascular smooth muscle [2].?

In canine pulmonary arterial smooth muscle cells exposed to 10 mM caffeine, ryanodine at the concentration of 10 μM reversibly inhibited induced Ca2+ increases [2]. In addition, ryanodine (0.4, 0.8, 1.6 and 10 μmol/L) was shown to differentiate between muscles of malignant hyperthermia (MH) susceptible and normal patients in terms of in vitro contracture response [3].?

In dogs, the lethal doses of ryanodine by injection were 50 ~ 300 μg/kg, which resulted in enophthalmos, followed by general spastic muscle rigidity, salivation, vomiting, and defecation. In mice, ryanodine exhibited low mammalian toxicity with intraperitoneal LD50 > 20 mg/kg, when compared with its toxicity on insects. Furthernomre, ryanodine affected the excitability and ion selectivity of K+ channels in insects but not in mammals [1].?

References:

[1]. Ujváry I. Chapter 3 - Pest Control Agents from Natural Products. Hayes' Handbook of Pesticide Toxicology (Third Edition). 2010, 119-229.

[2]. Ostrovskaya O, Goyal R, Osman N, et al. Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics, 2007, 323(1): 381-390.

[3]. Hopkins P M, Ellis F R, Halsall P J. Ryanodine contracture: a potentially specific in vitro diagnostic test for malignant hyperthermia. British Journal of Anaesthesia, 1991, 66(5): 611-613.

Product Citation

Chemical Properties

Physical AppearanceOff White solid
StorageDesiccate at -20°C
M.Wt493.55
Cas No.15662-33-6
FormulaC25H35NO9
Solubility<12.34mg/ml in DMSO;insoluble in ethanol
Chemical Name(3R,4R,4aR,4a1R,6R,6aR,7R,8S,8aR,9R,9aR)-4,4a1,6,7,8a,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate
Canonical SMILESO[C@@]1([C@@]([C@]2(C)C3)([C@H]4OC(C5=CC=CN5)=O)O)[C@]([C@@]4(C(C)C)O)(C)[C@]3(O)O[C@]1([C@@H]6O)[C@]2(CC[C@H]6C)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Ryanodine
 

User Guide

镇康县| 宣恩县| 台湾省| 舟曲县| 德令哈市| 东山县| 固阳县| 射阳县| 庐江县| 金华市| 邢台市| 喀什市| 宜宾县| 海淀区| 沅江市| 广灵县| 樟树市| 中超| 岳西县| 高尔夫| 信阳市| 泉州市| 雷波县| 东丽区| 长治市| 南雄市| 广饶县| 重庆市| 水城县| 聂荣县| 夏河县| 裕民县| 绵阳市| 十堰市| 正镶白旗| 青海省| 淮滨县| 玛沁县| 溆浦县| 龙岩市| 克什克腾旗|