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Y-320

Catalog No.
B3425
immunomodulator
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$110.00
In stock
2mg
$68.00
In stock
10mg
$159.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Y-320 is a new phenylpyrazoleanilide immunomodulator [1].

Immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.

Y-320 is a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells induced by IL-15 with IC50 values of 20-60 nM [1].

In type II collagen-induced arthritis (CIA) mice, oral administration of Y-320 (0.3-3 mg/kg) reduced IL-17 mRNA expression and significantly inhibited the development of joint destruction and arthritis. The combination of Y-320 with anti-murine tumor necrosis factor-α (TNF-α) monoclonal antibody exhibited a synergistic effect. In cynomolgus monkeys, Y-320 (0.3-1 mg/kg) relieved CIA. These results suggested that Y-320 could be a useful candidate for therapy of rheumatoid arthritis (RA) [1].

Reference:
[1].  Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel), 2013, 7(1): 1-17.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt505.01
Cas No.288250-47-5
FormulaC27H29ClN6O2
Solubility≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Chemical Name1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
Canonical SMILESCC1=C(C=NN1C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCOCC5)C#N
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description Y-320 is an orally active immunomodulator and inhibitor of IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
Targets            
IC50            

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Y-320
 

User Guide

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