Hydroxy Bupropion (CAS 357399-43-0) is a primary metabolite of the antidepressant bupropion. It functions through inhibition of dopamine and norepinephrine transporters, and exhibits antagonistic activity at α4β2 nicotinic receptors. In vitro investigations indicate that Hydroxy Bupropion modulates neurotransmitter signaling pathways. It holds potential for biomedical research focused on psychiatric disorders and nicotine addiction therapy.