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Trioxsalen

Catalog No.
C4451
intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light
Grouped product items
SizePriceStock Qty
100mg
$66.00
Ship with 5-10 days
250mg
$121.00
Ship with 5-10 days
500mg
$208.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Trioxsalen has been reported to intercalate into DNA forming DNA single-strand adducts and interstrand crosslinks when activated with UV light.

In vitro: Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage [1].

In vivo: Mice received 3H-trioxsalen either orally or intraperitoneally. It was found that over 88% of trioxsalen, after po or i.p. administration, was excreted in the urine within 8 hours and over 90% within 12 hours. The distribution patterns of trioxsalen radioactivity demonstrated that trioxsalen was selectively present in liver, skin, and blood and was barely detectable in other organs. The highest values were observed between 2 and 6 hours and diminished rapidly thereafter [1].

Clinical trial: In men receiving 40 mg unlabelled trioxsalen, 80% of the administered dose was excreted in urine within 8 hours as hydroxylated or glucuronide derivatives. It was also reported that trioxsalen transformed to a principal metabolite 5'-carboxy-4,8-dimethylpsoralen, which was found to be inactive as skin photosensitizer and to this transformation had been attributed the difference in the photoreactivity of trioxsalen when topically applied or systematically administered [1].

Reference:
[1] Mahmoud M. A. Hassan. Trioxsalen. Analytical Profiles of Drug Substances Volume 10, 1981, Pages 705-727.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt228.2
Cas No.3902-71-4
FormulaC14H12O3
SynonymsNSC 71047,4,5’,8-Trimethylpsoralen,Trisoralen
SolubilitySoluble in dichloromethane
Chemical Name2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
Canonical SMILESCc([o]c1c2C)cc1cc(C(C)=C1)c2OC1=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Trioxsalen
 

User Guide

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