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Kainic acid

Catalog No.
B6226
Selective kainate receptor agonist; for epilepsy and neurodegenerative disease models
Grouped product items
SizePriceStock Qty
1mg
$85.00
In stock
10mg
$303.00
Ship with 5-10 days
50mg
$1,092.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Kainic Acid (CAS 487-79-6) is a water-soluble heterocyclic dicarboxylic acid compound, functioning as a potent agonist of ionotropic glutamate receptors, specifically targeting kainate receptors in the central nervous system. It exhibits excitatory agonist activity toward these receptors, and also displays partial agonist effects on AMPA receptors. Additionally, it induces excitotoxicity by promoting persistent neuronal depolarization and calcium influx.

In experimental neuroscience research, Kainic Acid induces status epilepticus and seizure-like neuronal activity at nanomolar to micromolar concentrations, tested in various in vivo rodent animal models and in vitro neuronal cultures. It can also trigger hippocampal neurodegeneration, synaptic reorganization, and activation of glial cells, making it a widely used pharmacological tool for investigating mechanisms of neurotoxicity and epileptogenesis.

In the context of central nervous system disorder studies, Kainic Acid is widely used for modeling epilepsy, screening anticonvulsant drugs, and exploring excitotoxic pathways underlying neurodegenerative diseases. Its administration replicates seizure phenotypes and neuropathological changes observed in human temporal lobe epilepsy, facilitating the development and evaluation of neuroprotective strategies and antiepileptic therapeutics.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt213.23
Cas No.487-79-6
FormulaC10H15NO4
Synonyms2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid
Solubility≥11.05 mg/mL in H2O with gentle warming
Chemical Name(2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid
Canonical SMILESCC([C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1)=C
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Kainic acid
 

User Guide

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