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Protoporphyrin IX

Catalog No.
B8225
A final intermediate of the heme biosynthetic pathway
Grouped product items
SizePriceStock Qty
100mg
$50.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Protoporphyrin IX, widely distributed in all living cells in small amounts, is the final intermediate of the heme biosynthetic pathway. Chelation of Protoporphyrin IX with iron forms heme, which is a constituent of hemoproteins that play essential roles in a variety of biological events, such as oxygen transport, cellular oxidations and reductions, electron transport, as well as drug metabolism. Based on its photodynamic effects, Protoporphyrin IX has also been explored for cancer diagnosis and treatment. However, accumulation of Protoporphyrin IX in human porphyrias can lead to a series of symptoms including skin photosensitivity, hepatobiliary damage, biliary stones, and even liver failure.?

Reference:

1.?Sachar M, Anderson KE, Ma X. Protoporphyrin IX: the Good, the Bad, and the Ugly. Journal of Pharmacology and Experimental Therapeutics, 2016, 356(2): 267-275.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt562.66
Cas No.553-12-8
FormulaC34H34N4O4
Solubilityinsoluble in H2O; insoluble in EtOH; insoluble in DMSO
Canonical SMILESO=C(CCC1=C2/C=C3C(CCC(O)=O)=C(C(/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3)C)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

User Guide

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