Halofuginone (RU-19110), a derivative of Febrifugine, is a competitive inhibitor of prolyl-tRNA synthetase with a value of 18.3 nM.Halofuginone is a specific inhibitor of type I collagen synthesis and attenuates osteoarthritis through inhibitory activity.Halofuginone is also a potent pulmonary vasodilator that activates channels and blocks voltage-gated, receptor-operated, and store-operated channels.Halofuginone has antimalarial, anti-inflammatory, anticancer, and antifibrotic effects.