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Quinidine

Catalog No.
B7590
reduces both Na+ and K+ channel currents
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$61.00
In stock
50mg
$50.00
In stock
250mg
$116.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Quinidine is a clinical antiarrhythmic drug, which is used to treat abnormal heart rhythms and malaria[1].?

The application of quinidine in the bath results in a dose-dependent decrease in the peak amplitude of Ik. Kd for Ik block at 0 mV is estimated to be 41 μM[1].?

In rats, quinidine inhibits metabolism of amphetamine. Quinidine pretreatment significantly reduces excretion of p-hydroxyamphetamine at 24 and 48 hours, to 7.2% and 24.1% of vehicle control levels, and significantly increases excretion of amphetamine between 24 and 48 hours to 542%[2].?

Reference:

[1]. Kehl S J, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol, 1991, 103(3): 1807-13.

[2]. Moody D E, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol, 1990, 14(5): 311-7.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt324.42
Cas No.56-54-2
FormulaC20H24N2O2
Solubilityinsoluble in H2O; ≥10.32 mg/mL in EtOH with ultrasonic; ≥11.95 mg/mL in DMSO
Chemical Name(R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol
Canonical SMILESCOc(cc1)cc2c1nccc2[C@H]([C@@H](C[C@@H]1CC2)N2C[C@H]1C=C)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Quinidine
 

User Guide

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